A Different Script takes the audience into the lives of two actors with Down syndrome, a TV network star, Jamie Brewer, and a big dreamer, Chris Lopes. As we see how they use acting to transcend their limitations, we also see their place in a larger movement to include people with Down syndrome in the entertainment industry. This was largely spearheaded by their common talent agent, Gail Williamson, and her son, an actor with Down syndrome, Blair.